Work

A Naturally Occurring Variation in the Proline-Rich Region Does Not Attenuate Human Immunodeficiency Virus Type 1 Nef Function

Year: 2004

Type: article

Abstract: We analyzed human immunodeficiency virus type 1 (HIV-1) Nef variants to further evaluate the functional relevance of the R71T substitution previously proposed to attenuate viral replication (Fackler et al., Curr. Biol. 11:1294-1299, 2001). Our results demonstrate that this variation in the proline-rich region does not significantly affect the functional activity of Nef or HIV-1 infectivity or replication.

Source: Journal of Virology

DOI: 10.1128/jvi.78.18.10197-10201.2004

Authors: Elke Rücker, Jan Münch, Steffen Wildum, Matthias Brenner, Jutta Eisemann, Leonid Margolis, Frank Kirchhoff

Institutions: Universität Ulm, University Hospital Ulm, Friedrich-Alexander-Universität Erlangen-Nürnberg, National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2122601602

FWCI: 0.761

Cites: 29

Cited by: 8

Related to: 10