Work

Genetic Basis of Susceptibility to Drug-induced Liver Injury: What Have we Learned and where do we go from here?

Year: 2012

Type: article

Abstract: Drug-induced liver injury (DILI) is a rare but severe adverse drug reaction that represents a major problem in pharmacotherapy, both clinically and economically. A considerable effort has been made over the past several decades to identify genetic factors that predispose to risk for DILI, and the pace of discovery has vastly increased over just the past several years. Here, we describe the major findings in DILI pharmacogenetics with an emphasis on the recent results of unbiased genome-wide association studies, and suggest some directions for future research in this area.

Source: Pharmacogenomics

DOI: 10.2217/pgs.12.45

Authors: Thomas J Urban, David B Goldstein, Paul B Watkins

Institutions: Duke Medical Center, Duke University, University of North Carolina at Chapel Hill

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases