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Perivascular Adipose Tissue in Vascular Function and Disease: A Review of Current Research and Animal Models

Year: 2014
Type: review
Abstract: Perivascular adipose tissue (PVAT), long assumed to be nothing more than vessel-supporting connective tissue, is now understood to be an important, active component of the vasculature, with integral roles in vascular health and disease. PVAT is an adipose tissue with similarities to both brown and white adipose tissue, although recent evidence suggests that PVAT develops from its own precursors. Like other adipose tissue depots, PVAT secretes numerous biologically active substances that can act in both autocrine and paracrine fashion. PVAT has also proven to be involved in vascular inflammation. Although PVAT can support inflammation during atherosclerosis via macrophage accumulation, emerging evidence suggests that PVAT also has antiatherosclerotic properties related to its abilities to induce nonshivering thermogenesis and metabolize fatty acids. We here discuss the accumulated knowledge of PVAT biology and related research on models of hypertension and atherosclerosis.
DOI: 10.1161/atvbaha.114.303029
Authors: Nicholas K. Brown, Zhou Zhou, Jifeng Zhang, Rong Zeng, Jiarui Wu, Daniel T. Eitzman, Y. Eugene Chen, Lin Chang
Institutions: Children's National, Chinese Academy of Sciences, University of Michigan, Shanghai Institutes for Biological Sciences, Michigan Medicine, Center for Excellence in Molecular Cell Science
Language: English
Field: Medicine
Open Access status: bronze
Awards: Essential role of perivascular adipose tissue in blood pressure regulation, Nitroalkenes and Blood Pressure Regulation, Regenerating Blood Vessels Using iPS Cells, CRP Biology and Vascular Disease, Nitro-Fatty Acids and Nrf2 in Vascular Remodeling, PPAR-gamma and Vascular Disease
OpenAlex ID: W2122649866
FWCI: 4.112
Cites: 101
Cited by: 318
Related to: 10