Work

ALDH2, ADH1B, and ADH1C genotypes in Asians: a literature review.

Year: 2007

Type: article

Abstract: Variants of three genes encoding alcohol-metabolizing enzymes, the aldehyde dehydrogenase gene ALDH2 and the alcohol dehydrogenase genes ADH1B and ADH1C, have been associated with reduced rates of alcohol dependence. The genotype prevalence of these genes varies in general samples of different Asian ethnic groups. The ALDH2*2 allele appears to be most prevalent in Chinese-American, Han Chinese and Taiwanese, Japanese, and Korean samples. Much lower rates have been reported in Thais, Filipinos, Indians, and Chinese and Taiwanese aborigines. ADH1B*2 is highly prevalent among Asians, with the exception of Indians. ADH1C*1 also is highly prevalent in Asians, but has only been examined in a few studies of Chinese and Korean samples.

Source: Europe PMC (PubMed Central)

Authors: Mimy Y Eng, Susan E Luczak, Tamara L Wall

Institution: University of California San Diego

Language: English

Topic: Alcohol Consumption and Health Effects

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism

Awards: Childhood Precursors to Alcohol Involvement, Alcohol Research: Risk and Protection in Ethnic Groups, Alcohol Involvement in Asian American Men and Women, Alcohol Research in the Science/Practitioner Model