Work

A Multimodal Targeting Nanoparticle for Selectively Labeling T Cells

Year: 2008

Type: article

Abstract: A nanoparticle system capable of selectively labeling and monitoring antigen-specific cytotoxic T lymphocytes (CTLs) by magnetic resonance imaging and fluorescence reporting is demonstrated. These targeting nanoparticles were functionalized with tumor-specific peptide-major histocompatibility complex (MHC) (see figure). TEM and fluorescence microscopy reveal nanoparticle binding to the CTL membrane.

Source: Small

DOI: 10.1002/smll.200701103

Authors: Jonathan Gunn, Herschel Wallen, Omid Veiseh, Conroy Sun, Chen Fang, Jianhong Cao, Cassian Yee, Miqin Zhang

Institutions: University of Washington, Fred Hutch Cancer Center

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Institute of General Medical Sciences, National Institute of Biomedical Imaging and Bioengineering

Awards: G18591912, Multifuctional Nanovector For Diagnosis And Treatment Of Pediatric Brain Cancer, Nanotechnology Platform for Pediatric Brain Cancer Imaging and Therapy

OpenAlex ID: W2122690358

FWCI: 1.463

Cites: 20

Cited by: 47

Related to: 10