Work

Mechanical control of tissue and organ development

Year: 2010

Type: review

Abstract: Many genes and molecules that drive tissue patterning during organogenesis and tissue regeneration have been discovered. Yet, we still lack a full understanding of how these chemical cues induce the formation of living tissues with their unique shapes and material properties. Here, we review work based on the convergence of physics, engineering and biology that suggests that mechanical forces generated by living cells are as crucial as genes and chemical signals for the control of embryological development, morphogenesis and tissue patterning.

Source: Development

DOI: 10.1242/dev.024166

Authors: Tadanori Mammoto, Donald E. Ingber

Institutions: Boston Children's Hospital, Harvard University, Wyss Institute for Biologically Inspired Engineering

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: U.S. Department of Defense, National Institutes of Health, National Institute of Dental and Craniofacial Research

Award: SysCODE: Tooth Germ Design and Engineering (2 of 10)