Work

Arimetamycin A: Improving Clinically Relevant Families of Natural Products through Sequence‐Guided Screening of Soil Metagenomes

Year: 2013

Type: article

Abstract: Sequence-tag-guided screening of soil environmental DNA libraries can be used to guide the discovery of new compounds with improved properties. In heterologous expression experiments the eDNA-derived arm cluster encodes arimetamycin A, an anthracycline that is more potent than clinically used natural anthracyclines and retains activity against multidrug-resistant (MDR) cancer cells.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201305109

Authors: Hahk‐Soo Kang, Sean F. Brady

Institutions: Howard Hughes Medical Institute, Rockefeller University

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Howard Hughes Medical Institute, National Institute of General Medical Sciences