Genetics of Type 1 Diabetes: What's Next?
Year: 2010
Type: review
Abstract: The discovery of the association between HLA in the major histocompatibility complex (MHC) on chromosome 6p21 with type 1 diabetes, but not with type 2 diabetes, suggested that these disease entities were of different genetic background and pathogenesis. The discovery that some individuals with diabetes had autoantibodies in their blood provided additional evidence that type 1 diabetes had an autoimmune origin. Recently, increasing knowledge of the genome, coupled with rapidly improving genotyping technology and availability of increasingly large numbers of samples, has enabled statistically robust, systematic, genome-wide examinations for discovery of loci contributing to type 1 diabetes susceptibility, including within the MHC itself. Currently, there are over 50 non-HLA regions that significantly affect the risk for type 1 diabetes
Source: Diabetes
DOI: 10.2337/db10-0076
Institutions: Lund University, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, University of Virginia, Inserm, The University of Western Australia, Harry Perkins Institute of Medical Research, Breakthrough T1D, University of Cambridge, Breakthrough T1D UK, Addenbrooke's Hospital, Wellcome Trust
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
Funders: Juvenile Diabetes Research Foundation International, Wellcome Trust, National Institute for Health and Care Research, National Human Genome Research Institute, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Child Health and Human Development
OpenAlex ID: W2123367066