Work

Subtype C Is Associated with Increased Vaginal Shedding of HIV‐1

Year: 2005

Type: article

Study design: Observational Study

Abstract: The prevalence of human immunodeficiency virus (HIV)-1-infected cells and HIV-1 RNA levels in genital secretions and breast milk and the risk of mother-to-child transmission of HIV-1 were compared among subtypes A, C, and D in a Kenyan cohort. Pregnant women infected with subtype C were significantly more likely to shed HIV-1-infected vaginal cells than were those infected with subtype A or D (odds ratio [OR], 3.6 [95% confidence interval {CI}, 1.4-8.8]; P = .006). This relationship held after adjusting for age, CD4 cell count, and plasma HIV-1 RNA load (OR, 3.1 [95% CI, 1.1-8.6]; P = .03). These observations suggest that HIV-1 subtype influences mucosal shedding of HIV-1.

Source: The Journal of Infectious Diseases

DOI: 10.1086/431514

Authors: Grace C. John‐Stewart, Ruth W. Nduati, Christine M. Rousseau, Dorothy A. Mbori‐Ngacha, Barbra A. Richardson, Stephanie Rainwater, Dana D. Panteleeff, Julie Overbaugh

Institutions: University of Nairobi, University of Washington, Fred Hutch Cancer Center

Language: English

Topic: HIV/AIDS Research and Interventions

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases, Fogarty International Center, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G1255415169, Pediatric HIV-1 in Africa: Pathogenesis and Management, Graduate and Postdoctoral Training in Viral Oncology, AIDS International Training and Research Program, GENITAL SHEDDING AND INTRAPARTUM TRANSMISSION OF HIV-1, G7377736557, University of Washington/Fred Hutch Center for AIDS Research, Pediatric HIV reservoir determinants and consequences

OpenAlex ID: W2123404862

FWCI: 4.905

Cites: 18

Cited by: 85

Related to: 10