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A Thermodynamic Switch for Chromosome Colocalization

Year: 2008
Type: article
Abstract: A general model for the early recognition and colocalization of homologous DNA sequences is proposed. We show, on thermodynamic grounds, how the distance between two homologous DNA sequences is spontaneously regulated by the concentration and affinity of diffusible mediators binding them, which act as a switch between two phases corresponding to independence or colocalization of pairing regions.
Source: Genetics
DOI: 10.1534/genetics.107.083154
Institutions: Istituto Nazionale di Fisica Nucleare, University of Warwick, Istituto Nazionale di Fisica Nucleare, Sezione di Napoli, University of California, San Francisco, Institute of Genetics and Biophysics, National Research Council
Language: English
Open Access status: bronze
OpenAlex ID: W2123504278
FWCI: 1.52
Cites: 23
Cited by: 47
Related to: 10