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Human Cytomegalovirus Stimulates Cellular IKK2 Activity and Requires the Enzyme for Productive Replication

Year: 2004

Type: article

Abstract: Human cytomegalovirus (HCMV) exploits the host transcription factor NF-kappaB to enhance its own replication, dissemination, and reactivation from latency. Here we report that HCMV infection activates the upstream IkappaB kinase (IKK) complex and that its catalytic IKK2 subunit is required for HCMV-induced NF-kappaB activation, as well as the replication of different HCMV strains. These results indicate that IKK2 is essential for HCMV replication and emphasize the feasibility of blocking NF-kappaB activation as a way of inhibiting infection.

Source: Journal of Virology

DOI: 10.1128/jvi.78.6.3190-3195.2004

Authors: Patrizia Caposio, Michel Dreano, Gianni Garotta, Giorgio Gribaudo, Santo Landolfo

Institution: University of Turin

Language: English

Topic: Cytomegalovirus and herpesvirus research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2123551805

FWCI: 3.116

Cites: 26

Cited by: 40

Related to: 10