Work

Elimination of cotinine from body fluids: disposition in smokers and nonsmokers.

Year: 1989

Type: article

Abstract: We have evaluated differences in the elimination of cotinine, a major nicotine metabolite, in smokers who quit smoking and never-smokers who were exposed to environmental tobacco smoke (ETS) under controlled conditions. The mean biological half-life of cotinine in urine, collected from the nine smokers was 16.5 +/- 1.2 h, in never-smokers exposed to ETS, 27.3 +/- 1.9 h. Differences in the mode of uptake and absorption of nicotine and possible differences in nicotine metabolism may play roles in the clearance rate differences between smokers and nonsmokers.

Source: American Journal of Public Health

DOI: 10.2105/ajph.79.8.1046

Authors: N J Haley, D W Sepkovic, D Hoffmann

Institution: Institute for Cancer Prevention

Language: English

Topic: Smoking Behavior and Cessation

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute