Work

Regioselective Glycosylation: Synthesis of α-Indoline Nucleosides

Year: 2005

Type: article

Abstract: Novel indoline ribonucleosides with the alpha-N-glycoside configuration are synthesized with very high regioselectivity in 90-96%yield, using TMS protected indolines and 2,3-O-(1-methylethylidene)-5-O-(triphenylmethyl)-alpha/beta-D-ribofuranose. The structures of these ribonucleosides were elucidated with X-ray crystallography as well as 2D (NOESY, COSY, and HMQC) NMR spectroscopy.

Source: Nucleosides Nucleotides & Nucleic Acids

DOI: 10.1081/ncn-200067398

Authors: Kenneth L. Brown, Tilak Chandra, Shawn Zou, Edward J. Valente

Institutions: Ohio University, Mississippi College

Language: English

Topic: Carbohydrate Chemistry and Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: Mechanism of Enzyme Mediated Activation of Coenzyme B12