Work

The Elongation, Termination, and Recycling Phases of Translation in Eukaryotes

Year: 2012

Type: preprint

Abstract: This work summarizes our current understanding of the elongation and termination/recycling phases of eukaryotic protein synthesis. We focus here on recent advances in the field. In addition to an overview of translation elongation, we discuss unique aspects of eukaryotic translation elongation including eEF1 recycling, eEF2 modification, and eEF3 and eIF5A function. Likewise, we highlight the function of the eukaryotic release factors eRF1 and eRF3 in translation termination, and the functions of ABCE1/Rli1, the Dom34:Hbs1 complex, and Ligatin (eIF2D) in ribosome recycling. Finally, we present some of the key questions in translation elongation, termination, and recycling that remain to be answered.

Source: Cold Spring Harbor Perspectives in Biology

DOI: 10.1101/cshperspect.a013706

Authors: T. E. Dever, R. Green

Institutions: National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Award: Mechanism and Regulation of Eukaryotic Protein Synthesis