Additivity Principles in Biochemistry
Year: 1997
Type: review
Abstract: We cannot yet reliably fold proteins or RNA molecules by computer, predict ligand binding affinities, compute conformational transitions, or use the sequence information in the Human Genome very effectively to understand biomolecular function and disease. Why not? Perhaps some of our models in computational biology are based on flawed assumptions. Thermodynamic additivity principles are the foundations of chemistry, but few additivity principles have yet been found successful in biochemistry.
Source: Journal of Biological Chemistry
Author: Ken A. Dill
Institution: University of California, San Francisco
Language: English
Subfield: Physical and Theoretical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W2123768455