Work

A Stabilizing Influence: CAL PDZ Inhibition Extends the Half‐Life of ΔF508‐CFTR

Year: 2010

Type: article

Abstract: It pays to recycle! The most common mutation in cystic fibrosis (CF) impedes maturation and accelerates breakdown of the ion channel CFTR. A “stabilizer” has been characterized that blocks a PDZ domain responsible for CFTR degradation. The inhibitor iCAL36 extends the chloride channel's half-life in airway epithelial cells. It also complements the activity of a corrector of the maturation defect, thus suggesting the potential for combination CF therapies.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201005585

Authors: Patrick R. Cushing, Lars Vouilleme, Maria Pellegrini, Prisca Boisguerin, Dean R. Madden

Institutions: Dartmouth College, Charité – Universitätsmedizin Berlin

Language: English

Topic: Cystic Fibrosis Research Advances

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green