Molecular Mechanisms of Staphylococcus aureus Iron Acquisition
Year: 2010
Type: review
Abstract: The unique redox potential of iron makes it an ideal cofactor in diverse biochemical reactions. Iron is therefore vital for the growth and proliferation of nearly all organisms, including pathogenic bacteria. Vertebrates sequester excess iron within proteins in order to alleviate toxicity and restrict the amount of free iron available for invading pathogens. Restricting the growth of infectious microorganisms by sequestering essential nutrients is referred to as nutritional immunity. In order to circumvent nutritional immunity, bacterial pathogens have evolved elegant systems that allow for the acquisition of iron during infection. The gram-positive extracellular pathogen Staphylococcus aureus is a commensal organism that can cause severe disease when it gains access to underlying tissues. Iron acquisition is required for S. aureus colonization and subsequent pathogenesis. Herein we review the strategies S. aureus employs to obtain iron through the production of siderophores and the consumption of host heme.
Source: Annual Review of Microbiology
Authors: Neal D. Hammer, Eric P. Skaar
Institutions: Vanderbilt University, Vanderbilt University Medical Center
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G2675084885, G3879490787, The Contribution of Intracellular Heme Trafficking to Staphylococcal Pathogenesis, G594381234, G620767475, Mechanism and function of heme-iron utilization in staphylococcal pathogenesis, Southeast Regional Centers of Excellence for Biodefense & Emerging Infectious Di, Pathobiology of heme inducible transporters in Gram positive pathogens
OpenAlex ID: W2124064813