Opportunities and Challenges in the Era of Molecularly Targeted Agents and Radiation Therapy
Year: 2013
Type: article
Abstract: The first annual workshop for preclinical and clinical development of radiosensitizers took place at the National Cancer Institute on August 8-9, 2012. Radiotherapy is one of the most commonly applied and effective oncologic treatments for solid tumors. It is well recognized that improved clinical efficacy of radiotherapy would make a substantive impact in clinical practice and patient outcomes. Advances in genomic technologies and high-throughput drug discovery platforms have brought a revolution in cancer treatment by providing molecularly targeted agents for various cancers. Development of predictive biomarkers directed toward specific subsets of cancers has ushered in a new era of personalized therapeutics. The field of radiation oncology stands to gain substantial benefit from these advances given the concerted effort to integrate this progress into radiation therapy. This workshop brought together expert clinicians and scientists working in various disease sites to identify the exciting opportunities and expected challenges in the development of molecularly targeted agents in combination with radiation therapy.
DOI: 10.1093/jnci/djt055
Authors: Steven H. Lin, Thomas J. George, Edgar Ben-Josef, Jeffrey Bradley, Kevin S. Choe, Martin J. Edelman, Chandan Guha, Sunil Krishnan, Theodore S. Lawrence, Quynh-Thu Le, Bo Lu, Minesh Mehta, David Peereboom, Jann Sarkaria, Jinsil Seong, Dian Wang, Meng X. Welliver, C. Norman Coleman, Bhadrasain Vikram, Stephen Yoo, Christine H. Chung
Institutions: The University of Texas MD Anderson Cancer Center, University of Maryland Medical Center, Washington University in St. Louis, Hospital of the University of Pennsylvania, University of Florida, National Cancer Institute, University of Pennsylvania, The University of Texas Southwestern Medical Center, University of Maryland, Baltimore, Yeshiva University, University of Michigan, Stanford University, Thomas Jefferson University, Northwestern University, Cleveland Clinic, Mayo Clinic, Yonsei University, Medical College of Wisconsin, The Ohio State University, National Institutes of Health, Johns Hopkins University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2124175402