Work

Immune Promotion of Epithelial-mesenchymal Transition and Generation of Breast Cancer Stem Cells

Year: 2010

Type: article

Abstract: Elements of the immune system act as intimate regulators of cancer progression, inhibiting early stages of tumor growth, through immunosurveillance while facilitating later stages of tumor progression. Recent findings have revealed that activated CD8 T cells can stimulate mammary epithelial tumor cells to undergo epithelial-mesenchymal transition (EMT) and to acquire the greatly increased tumorigenic capability and chemotherapeutic resistance of breast cancer stem cells (BCSC). These studies provide a window to understanding how BCSC arise and are maintained within tumors, and how to best target these processes for therapeutic benefit.

Source: Cancer Research

DOI: 10.1158/0008-5472.can-09-4041

Authors: Jennifer M. Reiman, Keith L. Knutson, Derek C. Radisky

Institutions: Mayo Clinic, Mayo Clinic in Florida

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute