Neutralization of diverse human immunodeficiency virus type 1 variants by an anti-V3 human monoclonal antibody
Year: 1992
Type: article
Abstract: The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is thought to induce potent neutralizing antibodies which are generally defined as type specific and reactive with individual viral isolates. In contrast, the CD4-binding domain is thought to induce neutralizing antibodies that are group specific and capable of neutralizing all isolates of HIV-1. However, in this study, we used a panel of human monoclonal antibodies to these regions of gp120 which displays specificities and neutralizing activities that challenge these tenets. In particular, we used a human monoclonal antibody to the V3 domain with exceptionally potent and broad neutralizing activity against many diverse HIV-1 isolates. The anti-CD4-binding domain antibodies, on the other hand, showed a more restricted pattern of activity.
Source: Journal of Virology
Authors: M K Gorny, A J Conley, S Karwowska, A Buchbinder, J Y Xu, E A Emini, S Koenig, S Zolla-Pazner
Institutions: NYU Langone Health, New York University
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2124445678