Work

Cytoprotective nanoparticles by conjugation of a polyhis tagged annexin V to a nanoparticle drug

Year: 2014

Type: article

Abstract: We synthesized a cytoprotective magnetic nanoparticle by reacting a maleimide functionalized Feraheme (FH) with a disulfide linked dimer of a polyhis tagged annexin V. Following reductive cleavage of disulfide, the resulting annexin-nanoparticle (diameter = 28.0 ± 2.0 nm by laser light scattering, 7.6 annexin's/nanoparticle) was cytoprotective to cells subjected to plasma membrane disrupting chemotherapeutic or mechanical stresses, and significantly more protective than the starting annexin V. Annexin-nanoparticles provide an approach to the design of nanomaterials which antagonize the plasma membrane permeability characteristic of necrosis and which may have applications as cytoprotective agents.

Source: Nanoscale

DOI: 10.1039/c4nr06861k

Authors: Howard H. Chen, Hushan Yuan, Hoonsung Cho, David E. Sosnovik, Lee Josephson

Institutions: Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Chonnam National University

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of Biomedical Imaging and Bioengineering