Work

Making sense of cancer genomic data

Year: 2011

Type: preprint

Abstract: High-throughput tools for nucleic acid characterization now provide the means to conduct comprehensive analyses of all somatic alterations in the cancer genomes. Both large-scale and focused efforts have identified new targets of translational potential. The deluge of information that emerges from these genome-scale investigations has stimulated a parallel development of new analytical frameworks and tools. The complexity of somatic genomic alterations in cancer genomes also requires the development of robust methods for the interrogation of the function of genes identified by these genomics efforts. Here we provide an overview of the current state of cancer genomics, appraise the current portals and tools for accessing and analyzing cancer genomic data, and discuss emerging approaches to exploring the functions of somatically altered genes in cancer.

Source: Genes & Development

DOI: 10.1101/gad.2017311

Authors: Lynda Chin, William C. Hahn, Gad Getz, Matthew Meyerson

Institutions: Dana-Farber Cancer Institute, Dana-Farber/Harvard Cancer Center, Broad Institute, Massachusetts Institute of Technology

Language: English

Topic: Cancer Genomics and Diagnostics

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute