Work

Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform

Year: 2013

Type: article

Abstract: We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles.

Source: Chemical Communications

DOI: 10.1039/c3cc43618g

Authors: Anita Gianella, Aneta J. Mieszawska, Freek J. M. Hoeben, Henk M. Janssen, Peter A. Jarzyna, David P. Cormode, Kevin D. Costa, Satish Rao, Omid C. Farokhzad, Robert Langer, Zahi A. Fayad, Willem J. M. Mulder

Institutions: Icahn School of Medicine at Mount Sinai, SyMO-Chem (Netherlands), Brigham and Women's Hospital, Harvard University, Massachusetts Institute of Technology, Amsterdam UMC Location University of Amsterdam

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources

Awards: A Surface Activable Nanoemulsion platform for Breast Cancer Diagnosis and Therapy, Theranostic HDL nanoparticles for inflammatory macrophages in atherosclerosis, Integrated AFM and Real-Time Confocal Microscope Core, G6632036768, Theranostic nanoparticles to enhance morpholino delivery to the liver for suppres, G8807303853

OpenAlex ID: W2029142596

FWCI: 0.89

Cites: 11

Cited by: 16

Related to: 10