Work

Design of a single capillary-parenchymal co-culture bioreactor

Year: 2003

Type: conference-paper

Abstract: A bioreactor is designed and fabricated for the co-culture of endothelial and hepatic parenchymal cells. The device provides a structured environment mimicking the in vivo characteristics of a single capillary and the adjacent tissue. The bioreactor consists of two cell-scale fluid channels separated by a bio-compatible thin porous membrane made of self-assembling oligopeptide gel. Analytic and computational modeling techniques were used to investigate the fluid flow and mass transfer characteristics and aid in design of the bioreactor. Study of co-cultured cells in this device will contribute to the development of tissue-engineered organs.

DOI: 10.1109/iembs.2002.1137106

Authors: E.S. Kim, M.R. Kaazempur-Mofrad, J.T. Borenstein, J.P. Vacanti, R.D. Kamm

Institutions: Draper Laboratory, Massachusetts Institute of Technology, Harvard University, Massachusetts General Hospital

Language: English

Topic: 3D Printing in Biomedical Research

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W2124593204

FWCI:

Cites: 7

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Related to: 10