Work

Does control of mutant p53 by Mdm2 complicate cancer therapy?: Figure 1.

Year: 2008

Type: preprint

Abstract: Missense mutant forms of p53 are expressed at high levels in some human cancers and may contribute to oncogenesis. In this issue of Genes & Development, Terzian and colleagues (pp. 1337-1344) describe a mutant p53 knock-in mouse in which normal tissues and some tumors have low levels of mutant p53 protein unless Mdm2 or p16(INK4A) are absent. Once stabilized, mutant p53 promotes metastasis. Therefore, therapies that release p53 from Mdm2 might have unwanted consequences when cells have sustained a mutation in p53.

Source: Genes & Development

DOI: 10.1101/gad.1680508

Authors: Carol Prives, Eileen White

Institutions: Columbia University, Rutgers, The State University of New Jersey, Rutgers Cancer Institute

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2124807288

Cites: 62

Cited by: 30

Related to: 10