Year: 2009
Type: article
Abstract: Several genes that influence susceptibility to Alzheimer's disease (AD) have been known for over two decades. Recent advances have elucidated novel candidate genes and the pathogenetic mechanisms underlying neurodegeneration in AD. Here, we summarize what we have learned from studies of the known AD genes with regard to the causes of AD and emerging therapies. We also review key recent discoveries that have enhanced our understanding of the etiology and pathogenesis of this devastating disease, based on new investigations into the genes and molecular mechanisms underlying AD.
Source: F1000 Biology Reports
DOI: 10.3410/b1-54
Authors: Basavaraj V Hooli, Rudolph E Tanzi
Institutions: Massachusetts General Hospital, Harvard University
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: Cure Alzheimer's Fund
OpenAlex ID: W2124838156