Distinct roles of class I PI3K isoforms in multiple myeloma cell survival and dissemination
Year: 2014
Type: article
Abstract: The phosphoinositide 3-kinase (PI3K) pathway has a crucial role in tumor progression and drug resistance, including both conventional chemotherapeutics as well as novel agents. 1 Although no mutations have been described in the PI3K/Akt genes in multiple myeloma (MM), it was shown that this pathway is constitutively activated in MM cells and has pleiotropic effects influencing proliferation, drug resistance, angiogenesis and cell adhesion. 2
Source: Blood Cancer Journal
DOI: 10.1038/bcj.2014.24
Authors: I Sahin, M Moschetta, Y Mishima, S V Glavey, B Tsang, F Azab, S Manier, Y Zhang, P Maiso, A Sacco, A K Azab, A M Roccaro, I M Ghobrial
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,290
Funder: National Cancer Institute
OpenAlex ID: W2124893415