Work

Touch spray mass spectrometry for in situ analysis of complex samples

Year: 2014

Type: article

Abstract: Touch spray, a spray-based ambient in situ ionization method, uses a small probe, e.g. a teasing needle to pick up sample and the application of voltage and solvent to cause field-induced droplet emission. Compounds extracted from the microsample are incorporated into the sprayed micro droplets. Performance tests include disease state of tissue, microorganism identification, and therapeutic drug quantitation. Chemical derivatization is performed simultaneously with ionization.

Source: The Analyst

DOI: 10.1039/c4an00548a

Authors: Kevin S. Kerian, Alan K. Jarmusch, R. Graham Cooks

Institution: Purdue University West Lafayette

Language: English

Topic: Mass Spectrometry Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Purdue University, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Biomedical Imaging and Bioengineering

Awards: Desorption Electrospray Ionization Mass Spectrometry Imaging in Clinical Diagnost, Development of a Point-of-Care Mass Spectrometry Analysis System