Work

CD8+T Cells Maintain Suppression of Simian Immunodeficiency Virus in the Central Nervous System

Year: 2014

Type: article

Abstract: Human immunodeficiency virus (HIV) accesses the brain early in infection and can lead to neurocognitive disorders. The brain can also serve as a viral reservoir, but how virus is controlled in the brain is unknown. To examine this, CD8-depleting monoclonal antibody was injected into the cerebrospinal fluid of rhesus monkeys with chronic simian immunodeficiency virus (SIV) infection. This treatment led to the rapid increase of SIV in the brain. Virus in the brain is maintained by active suppression from the host immune system. This dynamic interaction can be manipulated in efforts to control and eradicate virus from the brain and other reservoirs.

Source: The Journal of Infectious Diseases

DOI: 10.1093/infdis/jiu401

Authors: Maria Cecilia G. Marcondes, Brenda Morsey, Katy Emanuel, Benjamin G. Lamberty, Claudia T. Flynn, Howard S. Fox

Institutions: Scripps Research Institute, University of Nebraska Medical Center

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute of Mental Health, National Institute on Drug Abuse