Work

Enhanced Pathogenesis of an Attenuated Herpes Simplex Virus for Mice Lacking Stat1

Year: 2008

Type: article

Abstract: Mice lacking the Stat1 interferon signaling gene were infected with herpes simplex virus type 1 (HSV-1) or an attenuated recombinant lacking virion host shutoff (Delta vhs). Delta vhs virus-infected Stat1(-/-) mice showed levels of replication equivalent to that of the wild-type virus-infected control mice but reduced relative to wild-type virus-infected Stat1(-/-) mice. Stat1 deficiency relieves the immunomodulatory deficiency of Delta vhs virus, but not its inherent growth defect. Also Vhs is dispensable for reactivation.

Source: Journal of Virology

DOI: 10.1128/jvi.00297-08

Authors: Tracy Jo Pasieka, Betty Lu, David A. Leib

Institution: Washington University in St. Louis

Language: English

Topic: Herpesvirus Infections and Treatments

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Research to Prevent Blindness, National Institutes of Health, National Eye Institute, National Institute of Allergy and Infectious Diseases