Approaching the in vitro clinical trial: engineering organs on chips
Year: 2014
Type: article
Abstract: In vitro cell culture and animal models are the most heavily relied upon tools of the pharmaceutical industry. When these tools fail, the results are costly and have at times, proven deadly. One promising new tool to enhance preclinical development of drugs is Organs on Chips (OOCs), proposed as a clinically and physiologically relevant means of modeling health and disease. Bringing the patient from bedside to bench in this form requires that the design, build, and test of OOCs be founded in clinical observations and methods. By creating OOCs as models of the patient, the industry may be better positioned to evaluate medicinal therapeutics.
Source: Lab on a Chip
DOI: 10.1039/c4lc00276h
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
Funders: National Institutes of Health, Harvard School of Engineering and Applied Sciences, Hansjörg Wyss Institute for Biologically Inspired Engineering, Harvard University, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Center for Advancing Translational Sciences
OpenAlex ID: W2125370350