Work

Why there are two cyclooxygenase isozymes

Year: 2001

Type: review

Abstract: Prostaglandins and their precursorsPhysiological processes for which PGHS-2 is responsible Ovulation and implantation.PGHS-2-null female mice are infertile (3).Although follicular development is observed in PGHS-2-deficient mice, ovulation is greatly reduced and, of the eggs released, very few are fertilized (8).Ovarian PGE 2 production is increased by pituitary gonadotropins in wild-type and PGHS-1-null mice, but not in PGHS-2-null mice, indicating that PGHS-2 is responsible for this increased ovarian PGE 2 production.Because ovulation in PGHS-2-null mice can be restored by PGE 2 administration (11), PGE 2 formed via PGHS-2 is believed to be the product that is responsible for ovulation.In addition to affecting ovu-Why there are two cyclooxygenase isozymes

Source: Journal of Clinical Investigation

DOI: 10.1172/jci13271

Authors: William L. Smith, Robert Langenbach

Institutions: Michigan State University, National Institute of Environmental Health Sciences

Language: English

Topic: Inflammatory mediators and NSAID effects

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases