Year: 2014
Type: review
Abstract: The clinical manifestations of asthma are caused by obstruction of the conducting airways of the lung. Two airway cell types are critical for asthma pathogenesis: epithelial cells and smooth muscle cells. Airway epithelial cells, which are the first line of defense against inhaled pathogens and particles, initiate airway inflammation and produce mucus, an important contributor to airway obstruction. The other main cause of airway obstruction is contraction of airway smooth muscle. Complementary experimental approaches involving cultured cells, animal models, and human clinical studies have provided many insights into diverse mechanisms that contribute to airway epithelial and smooth muscle cell pathology in this complex disease.
Source: The Journal of Cell Biology
Authors: David J. Erle, Dean Sheppard
Institution: University of California, San Francisco
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: In Vivo Function of Pulmonary Integrins, Micro-RNAs in airway epithelial differentiation and asthma, G3356337642, G358049942, Integrin-mediated Regulation of Airway Smooth Muscle, Specialized molecules with essential roles in mucus production, In Vivo Function of Pulmonary Integrins, G9000014683, Immune-driven Airway Epithelial Dysfunction in Muco-obstructive Asthma
OpenAlex ID: W2125457360