Effects of Smoking on Serum SOD and GSH-PX Activities and MDA Contents in Rats with Gastric Ulcer
Year: 2014
Type: article
Abstract: In this study, SD rats were used to establish an acetic acid-induced rat gastric ulcer model, and SOD and GSH-PX activities and MDA contents in rats with the gastric ulcer induced by acetic acid were measured. The results showed that smoking could delay the healing of gastric ulcer induced by acetic acid and aggravate the ulceration; compared with those in the model group, serum SOD, GSH-PX activities were significantly reduced, and MDA levels were significantly elevated, in rats with the gastric ulcer induced by acetic acid, suggesting that smoking may reduce the body's antioxidant capacity. The results indicate that smoking may induce or aggravate gastric ulcer by reducing the activity of serum SOD and GSH-PX, and elevating the content of serum MDA in rats with acetic acid-induced gastric ulcer, to affect the metabolism of oxygen free radicals to cause the oxidative damage.
Source: Applied Mechanics and Materials
Authors: Shu Jing, Wei Hai Jiang, Wei Sun
Institution: Beihua University
Language: English
Subfield: Biochemistry (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2125567210