Year: 2014
Type: preprint
Abstract: Accumulating evidence has documented a role for B cells and antibodies (Abs) in the immunity against Mycobacterium tuberculosis (Mtb). Passive transfer studies with monoclonal antibodies (mAbs) against mycobacterial antigens have shown protection against the tubercle bacillus. B cells and Abs are believed to contribute to an enhanced immune response against Mtb by modulating various immunological components in the infected host including the T-cell compartment. Nevertheless, the extent and contribution of B cells and Abs to protection against Mtb remains uncertain. In this article we summarize the most relevant findings supporting the role of B cells and Abs in the defense against Mtb and discuss the potential mechanisms of protection.
Authors: J. M. Achkar, J. Chan, A. Casadevall
Institution: Albert Einstein College of Medicine
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1593697378, G1750079537, G1828636376, G2019266947, Immunodiagnostic Tests for the Rapid Diagnosis of Tb, G234908501, G2436179761, Synergy of Host Defense Mechanisms in the Lung, G2773611754, G2965176016, G2982596766, G3262297016, G3501732833, G356915196, G3814909541, Center for AIDS Research (CFAR), G4559384, G4617214234, G5244102243, G5283553752, Discovery of Biological and Immunological Biomarkers for TB Vaccines, G641029318, G6463564890, Protective antibodies for Cryptococcal Infections, Biology of Fungal Melanin, G9000121821, G9000205050, Molecular Characterization of C. neoformans Antibodies
OpenAlex ID: W2125568747