Oxidative Protein Damage Is Associated With Elevated Serum Interleukin-6 Levels Among Older Moderately to Severely Disabled Women Living in the Community
Year: 2008
Type: article
Abstract: BACKGROUND: Elevated interleukin (IL)-6 is associated with adverse outcomes. Our objective was to determine whether serum protein carbonyls, an indicator of oxidative protein damage and oxidative stress, were associated with IL-6. METHODS: Serum protein carbonyls and IL-6 were measured in 739 women, age > or =65 years, in the Women's Health and Aging Study I. RESULTS: Geometric mean of protein carbonyls was 0.082 nmol/mg. After adjusting for age and smoking status, log(e) serum protein carbonyls were associated with log(e) IL-6 (beta = 0.143, standard error [SE] = 0.048, p =.003) in linear regression analyses and with elevated IL-6 (> or =2.5 pg/mL) (odds ratio = 1.38, 95% confidence interval, 1.02-1.86, p =.037) in logistic regression analyses. CONCLUSION. Oxidative damage to proteins is independently associated with serum IL-6 among older women living in the community. Increased oxidative stress may be a factor involved in the pathogenesis of the proinflammatory state that occurs in older adults.
Language: English
Subfield: Biochemistry
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1699328781, GENERAL CLINICAL RESEARCH CENTER, G308843618, WOMEN'S HEALTH AND AGING, Oxidative stress and the pathogenesis of sarcopenia and disability in older women, G4629504595, Adjunct Vitamin A Therapy for Tuberculosis and HIV/AIDS, G7423759087, RISK FACTORS FOR PHYSICAL DISABILITY IN AGING WOMEN
OpenAlex ID: W2125949769