Vascular Endothelial Growth Factors B and C: Gene Regulation and Gene Transfer In Vivo
Year: 2004
Type: dissertation
Abstract: 10 REVIEW OF THE LITERATURE 11 THE VASCULAR SYSTEM 11 THE BLOOD VASCULAR SYSTEM 11 Embryonic Development, Structure and Function 11 Angiogenesis in the Adult 12 MOLECULAR REGULATORS OF THE BLOOD VASCULAR SYSTEM 14 VEGF 14 VEGF-B 15 PlGF 16 VEGF Homologues Encoded by Orf and Parapox Viruses 17 VEGFR-2 and VEGFR-1 17 Neuropilins 18 Ephs and Ephrins 18 Platelet Derived Growth Factors (PDGFs) 18 Angiopoietins and Tie Receptors 19 MARKERS OF THE VASCULAR SYSTEM 19 PECAM-1 19 vWF 20 VE-cadherin 20 PATHOLOGIC ANGIOGENESIS AND ARTERIOGENESIS 21 Angiogenesis in Ischemic Disease 21 Arteriogenesis 21 Tumor Angiogenesis 22 THE LYMPHATIC SYSTEM 23 Embryonic Development, Structure and Function 23 MOLECULAR REGULATORS OF THE LYMPHATIC SYSTEM 25 VEGF-C and VEGF-D 25 VEGFR-3 26 MARKERS OF THE LYMPHATIC SYSTEM 27 Lymphatic Vessel Endothelial Hyaluronan Receptor-1 (LYVE-1) 27 Podoplanin 27 Prox-1 27 PATHOLOGIC LYMPHANGIOGENESIS 28 Tumor Lymphangiogenesis 28 Lymphedemas 28 THERAPEUTIC APPROACHES 30 Vascular Gene Therapy 30 Viral Vectors 30 Proangiogenic Therapy 31 Lymphangiogenic Therapy 31 AIMS OF THE STUDY 32 MATERIALS AND METHODS 33 RESULTS AND DISCUSSION 35 I. STUDIES ON THE REGULATION OF VEGF, VEGF-B, VEGF-C AND ANG-1 MRNA EXPRESSION 35 II. PROINFLAMMATORY CYTOKINES REGULATE EXPRESSION OF VEGF-C 36 III. ADENOVIRAL EXPRESSION OF VEGF-C IN THE SKIN INDUCES LYMPHANGIOGENESIS 39 IV. VEGF-B ACTIVATES VEGFR-1, BUT PROVIDES VERY LITTLE ANGIOGENIC OR ARTERIOGENIC ACTIVITY IN VIVO IN COMPARISON WITH PLGF 40 CONCLUDING REMARKS 42
Source: Työväentutkimus Vuosikirja
Author: Berndt Enholm
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2126107465