Work

NO/redox disequilibrium in the failing heart and cardiovascular system

Year: 2005

Type: review

Abstract: There is growing evidence that the altered production and/or spatiotemporal distribution of reactive oxygen and nitrogen species creates oxidative and/or nitrosative stresses in the failing heart and vascular tree, which contribute to the abnormal cardiac and vascular phenotypes that characterize the failing cardiovascular system. These derangements at the integrated system level can be interpreted at the cellular and molecular levels in terms of adverse effects on signaling elements in the heart, vasculature, and blood that subserve cardiac and vascular homeostasis.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci24459

Authors: Joshua M. Hare, Jonathan S. Stamler

Institutions: Johns Hopkins University, Johns Hopkins Medicine, Duke University

Language: English

Topic: Nitric Oxide and Endothelin Effects

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Donald W. Reynolds Foundation, National Heart, Lung, and Blood Institute