Work

Gentian Violet Exhibits Activity against Biofilms Formed by Oral Candida Isolates Obtained from HIV-Infected Patients

Year: 2011

Type: article

Abstract: The effect of gentian violet against Candida albicans and non-Candida albicans biofilms formed on polymethylmethacrylate strips was evaluated using a dry weight assay and confocal laser scanning microscopy. The ability of gentian violet to inhibit Candida albicans germination was also assessed. Gentian violet activity against Candida biofilms was demonstrated by a reduction in dry weight, disruption of biofilm architecture, and reduced biofilm thickness. Additionally, gentian violet inhibited Candida germination in a concentration-dependent manner.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01601-10

Authors: Rana S. Traboulsi, Pranab K. Mukherjee, Jyotsna Chandra, Robert A. Salata, Richard Jurevic, Mahmoud A. Ghannoum

Institutions: University Hospitals Cleveland Medical Center, Case Western Reserve University

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Institute of Dental and Craniofacial Research