Work

RAF/MEK Dependence of KRAS-Mutant Pancreatic Ductal Adenocarcinomas

Year: 2012

Type: article

Abstract: Summary: Studies using genetically engineered mouse models indicate that RAF activation is sufficient to induce pancreatic intraepithelial neoplasms, suggesting that mitogen-activated protein kinase (MAPK)/extracellular signal–regulated kinase (ERK) kinase (MEK) inhibitor–based combination approaches may have clinical use in patients with pancreatic ductal adenocarcinomas. Cancer Discov; 2(8); 666–9. ©2012 AACR. Commentary on Collisson et al., p. 685.

Source: Cancer Discovery

DOI: 10.1158/2159-8290.cd-12-0308

Authors: Aphrothiti J. Hanrahan, David B. Solit

Institution: Memorial Sloan Kettering Cancer Center

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute