Dual-Specificity CAR+ T Cells to Target B-Cell Malignancies and Opportunistic Fungal Infection
Year: 2014
Type: article
Abstract: Lymphodepletion before adoptive cell transfer (ACT) can enhance anti-tumor responses by increasing access to homeostatic cytokines and by depressing the numbers of regulatory cells. However, the lymphodepleted recipient is at risk for morbidity and mortality from pathogens. Indeed, opportunistic invasive fungal infection (IFI) by Aspergillus sp. results in a 60 to 85% in patients undergoing hematopoietic stem-cell transplantation. Antifungal agents such as polyenes, triazoles, and echinocandins can be rendered ineffective due to shifts in fungal epidemiology, emergence of drug resistant strains, and attendant toxicities in the recipients.
Institution: The University of Texas MD Anderson Cancer Center
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2126633633