Year: 2013
Type: article
Abstract: This issue of Neurosurgical Focus contains a collection of articles related to changing treatment paradigms for intracerebral hemorrhage. Intracerebral hemorrhage from a variety of causes has been an understudied phenomenon given its prevalence and devastating consequences. New information about natural history, factors influencing outcome, elucidation of additional pathophysiological mechanisms, and neurointensive care management has led to a renewed enthusiasm to improve outcome based on rational treatment paradigms. More recently the introduction of many new anticoagulants and antiplatelet agents has presented new management dilemmas for physicians caring for patients with intracerebral hemorrhage. This collection of interesting papers will hopefully update the reader on current management controversies as well as emerging treatments that may offer promise to improve outcomes in these patients in the future. The first article by Kelly et al. outlines the challenge of surgical decision making when confronted with patients with intracerebral hemorrhage. This timely review summarizes a number of studies regarding the natural history of the condition and factors that influence outcome and are related to the treatment recommendations made to patients and families. The article points out that factors, including geography, treatment biases, patient perceptions, and physician biases, can have a major influence on decision making and selection of different treatments for patients with intracerebral hemorrhages. The next article by Goren and associates focuses on modern intraoperative imaging modalities and how they may be employed in identifying vascular lesions that may be the cause of intracerebral hemorrhage. In the past, the etiology of hemorrhages were often presumed based on characteristic CT appearance, but the important recognition of underlying vascular lesions has been made easier by advances in modern imaging modalities that this article nicely outlines. The next 3 articles deal with the role of decompressive hemicraniectomy in intracerebral hemorrhage patients who are surgically treated and rationales for use of this technique to try to preserve viable brain tissue when treating hemorrhages surgically. The subsequent articles, one by James et al. and the other by Awad et al., detail the use of anticoagulants, antiplatelet agents, and newer agents including Dabigatran and the need for reversal of the effects of these agents in the management of intracerebral hemorrhage. The common use of some of the newer agents for anticoagulation therapy and antiplatelet therapy and their different durations of action, as well as different strategies of reversal of these agents, has required new protocols to be put in place. Close cooperation with blood banks can help effect the reversal of these agents in these patients to limit the expansion of the hemorrhage and can be a prerequisite for surgery, when contemplating surgical treatment. The article by James et al., “The role of anticoagulants, antiplatelet agents, and their reversal strategies in the management of intracerebral hemorrhage,” provides a detailed review of the pathophysiology of these agents and effective treatment strategies. There is a very useful table at the end that will be valuable as a reference guide for clinicians treating these patients. Neugebauer et al. provide a thorough review of the role of managing cerebellar infarction associated with mass effect and various management strategies including ventricular drainage, observation, and surgery. There is a Introduction
Source: Neurosurgical FOCUS
Author: David W. Newell
Institution: Swedish Medical Center
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2126634909