Work

The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis

Year: 2014

Type: article

Abstract: The ATPase valosin-containing protein (VCP)/p97 has emerged as a central and important element of the ubiquitin system. Together with a network of cofactors, it regulates an ever-expanding range of processes that stretch into almost every aspect of cellular physiology. Its main role in proteostasis and key functions in signaling pathways are of relevance to degenerative diseases and genomic stability. In this Cell Science at a Glance and the accompanying poster, we give a brief overview of this complex system. In addition, we discuss the pathogenic basis for VCP/p97-associated diseases and then highlight in more detail new exciting links to the translational stress response and RNA biology that further underscore the significance of the VCP/p97 system.

Source: Journal of Cell Science

DOI: 10.1242/jcs.093831

Authors: Hemmo Meyer, Conrad C. Weihl

Institutions: University of Duisburg-Essen, Washington University in St. Louis, Hope Center for Neurological Disorders

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute on Aging