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Novel Acyclic Nucleoside Phosphonate Analogues with Potent Anti-Hepatitis B Virus Activities

Year: 2005

Type: article

Abstract: Novel acyclic nucleoside phosphonates with a pyrimidine base preferentially containing an amino group at C-2 and C-4 and a 2-(phosphonomethoxy)ethoxy or (R)-2-(phosphonomethoxy)propoxy group at C-6 selectively inhibit the replication of wild-type and lamivudine-resistant hepatitis B viruses. The activity of the most potent compounds was comparable to that of adefovir.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.49.3.1177-1180.2005

Authors: C. Ying, A. Holý, D. Hocková, Z. Havlas, E. De Clercq, J. Neyts

Institutions: Rega Institute for Medical Research, Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry

Language: English

Topic: Hepatitis B Virus Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2126903585

FWCI: 4.301

Cites: 12

Cited by: 50

Related to: 10