Work

Polarized Protein Transport and Lumen Formation During Epithelial Tissue Morphogenesis

Year: 2015

Type: review

Abstract: One of the major challenges in biology is to explain how complex tissues and organs arise from the collective action of individual polarized cells. The best-studied model of this process is the cross talk between individual epithelial cells during their polarization to form the multicellular epithelial lumen during tissue morphogenesis. Multiple mechanisms of apical lumen formation have been proposed. Some epithelial lumens form from preexisting polarized epithelial structures. However, de novo lumen formation from nonpolarized cells has recently emerged as an important driver of epithelial tissue morphogenesis, especially during the formation of small epithelial tubule networks. In this review, we discuss the latest findings regarding the mechanisms and regulation of de novo lumen formation in vitro and in vivo.

Source: Annual Review of Cell and Developmental Biology

DOI: 10.1146/annurev-cellbio-100814-125323

Authors: Alex J. Blasky, Anthony Mangan, Rytis Prekeris

Institution: University of Colorado Anschutz

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Predoctoral Training Program in Molecular Biology, Molecular Mechanisms Regulating Epithelial Cell Apical Polarity and Ciliogenesis