Pharmacokinetics of Anidulafungin in Pleural Fluid during the Treatment of a Patient with Candida Empyema
Year: 2011
Type: article
Study design: Case Report
Abstract: Candida empyema is a serious complication of disseminated candidiasis. However, little is known about the intrapleural pharmacokinetics of echinocandins. We report the penetration of anidulafungin into the pleural fluid of a patient with Candida tropicalis empyema. The anidulafungin ratio for the area under the concentration-time curve from 0 h to the last measurement between pleural fluid and serum values was only 0.125 (12.5%), with pleural fluid concentrations ranging between 0.67 and 0.88 μg/ml.
DOI: 10.1128/aac.01560-10
Institutions: National Institutes of Health, National Institutes of Health Clinical Center, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, The University of Texas at San Antonio Health Science Center, National Cancer Institute, NewYork–Presbyterian Hospital, Cornell University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: National Institutes of Health
OpenAlex ID: W2127116329