Histone Ubiquitination and Deubiquitination in Transcription, DNA Damage Response, and Cancer
Year: 2012
Type: article
Abstract: Histone post-transcriptional modifications play essential roles in regulation of all DNA related processes. Among them, histone ubiquitination has been discovered for more than three decades. However, its functions are still less well understood than other histone modifications such as methylation and acetylation. In this review, we will summarize our current understanding of histone ubiquitination and deubiquitination. In particular, we will focus on how they are regulated by histone ubiquitin ligases and deubiquitinating enzymes. We will then discuss the roles of histone ubiquitination in transcription and DNA damage response and the crosstalk between histone ubiquitination and other histone modifications. Finally, we will review the important roles of histone ubiquitination in stem cell biology and cancer.
Source: Frontiers in Oncology
Institution: Yale University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
Funders: Alexander and Margaret Stewart Trust, Breast Cancer Alliance, Melanoma Research Alliance, Yale University, Yale Cancer Center, Georgia Clinical and Translational Science Alliance, National Institutes of Health, National Cancer Institute, National Center for Research Resources, National Center for Advancing Translational Sciences, Yale Center for Clinical Investigation, Yale School of Medicine
OpenAlex ID: W2127180680