Prefrontal Plasticity and Stress Inoculation-Induced Resilience
Year: 2009
Type: article
Abstract: Coping with mild early life stress tends to make subsequent coping efforts more effective and therefore more likely to be used as a means of arousal regulation and resilience. Here we show that this developmental learning-like process of stress inoculation increases ventromedial prefrontal cortical volumes in peripubertal monkeys. Larger volumes do not reflect increased cortical thickness but instead represent surface area expansion of ventromedial prefrontal cortex. Expansion of ventromedial prefrontal cortex coincides with increased white matter myelination inferred from diffusion tensor magnetic resonance imaging. These findings suggest that the process of coping with early life stress increases prefrontal myelination and expands a region of cortex that broadly controls arousal regulation and resilience.
Source: Developmental Neuroscience
DOI: 10.1159/000216540
Institutions: Stanford Medicine, Stanford University, University of Geneva
Language: English
Subfield: Behavioral Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: Maternal Availability and Postnatal Brain Development, High Resolution Diffusion-Weighted Magnetic Resonance Imaging at 300-Micron Level, High Resolution Diffusion-Weighted Magnetic Resonance Imaging at 300-Micron Level, Early Chronic Stress and Prefrontal Development, Neurobiology of Stress Inoculation, Model of Hypercortisolism for Major Depression
OpenAlex ID: W2127372492