Work

Oncogene Activation in Myeloid Leukemias by Graffi Murine Leukemia Virus Proviral Integration

Year: 1999

Type: article

Abstract: The Graffi murine leukemia virus (MuLV) is a nondefective retrovirus that induces granulocytic leukemia in BALB/c and NFS mice. To identify genes involved in Graffi MuLV-induced granulocytic leukemia, tumor cell DNAs were examined for genetic alterations at loci described as common proviral integration sites in MuLV-induced myeloid, lymphoid, and erythroid leukemias. Southern blot analysis revealed rearrangements in c-myc, Fli-1, Pim-1, and Spi-1/PU.1 genes in 20, 10, 3.3, and 3.3% of the tumors tested, respectively. These results demonstrate for the first time the involvement of those genes in granulocytic leukemia.

Source: Journal of Virology

DOI: 10.1128/jvi.73.5.4439-4442.1999

Authors: Catherine Denicourt, Elsy Edouard, Eric Rassart

Institution: Université du Québec à Montréal

Language: English

Topic: T-cell and Retrovirus Studies

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Cancer Research Society, National Cancer Institute