Identification of Two Nervous System-Specific Members of theergPotassium Channel Gene Family
Year: 1997
Type: article
Abstract: Two new potassium channel genes, erg2 and erg3, that are expressed in the nervous system of the rat were identified. These two genes form a small gene family with the previously described erg1 (HERG) gene. The erg2 and erg3 genes are expressed exclusively in the nervous system, in marked contrast to erg1, which is expressed in both neural and non-neural tissues. All three genes are expressed in peripheral sympathetic ganglia. The erg3 channel produces a current that has a large transient component at positive potentials, whereas the other two channels are slowly activating delayed rectifiers. Expression of the erg1 gene in the sympathetic nervous system has potential implications for the etiology of the LQT2 form of the human genetic disease long QT syndrome.
Source: Journal of Neuroscience
Authors: Wenmei Shi, Randy S. Wymore, Hong-Sheng Wang, Zongming Pan, Ira S. Cohen, David McKinnon, Jane E. Dixon
Institutions: Stony Brook University, State University of New York
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Awards: TROPHIC CONTROL OF ELECTROPHYSIOLOGICAL PHENOTYPE, G3628949866, G4481860625, CARDIAC ELECTROPHYSIOLOGY: EFFECTS OF IONS AND DRUGS, CARDIAC ELECTROPHYSIOLOGY--EFFECTS OF IONS AND DRUGS, Molecular Physiology--Control of Firing Properties, The Biochemistry and Cell Biology of Metabolic Diseases, G985837625
OpenAlex ID: W2127474777